Molybdenum cofactor sulfurase (MOCOS) is an enzyme participating in purine metabolism. The aim of current study was to evaluate the role of a single nucleotide polymorphism (SNP) in the coding gene (rs594445) in mood disorders and methamphetamine addiction.

This SNP was genotyped in 200 persons with methamphetamine addiction, 85 patients with bipolar disorder 1 (BP1), 78 patients with BP2, 33 patients with major depressive disorder (MDD) and 200 age-/sex-matched normal subjects using the tetra-primer amplification-refractory mutation system (ARMS)-PCR technique.

The rs594445 was associated with methamphetamine addiction in co-dominant model [A/A vs C/C: OR (95% CI) = 0.466 (0.252–0.864), P-value = 0.014; C/A vs C/C: OR (95% CI) = 0.641 (0.418–0.981), P-value = 0.04]. This SNP was also associated with this trait in dominant model [OR (95% CI) = 0.591 (0.398–0.879), P-value = 0.009]. The A allele of rs594445 had a protective role against methamphetamine addiction [A vs C: OR (95% CI) = 0.645 (0.48–0.866), P-value = 0.004]. The rs594445 was associated with BP1 in co-dominant model [C/A vs C/C: OR (95% CI) = 0.423 (0.230–0.778), P-value = 0.005]. However, the associations were insignificant in other inheritance models.

Finally, there were no significant associations between the mentioned SNP and risk of BP2 or MDD in any inheritance model. The present project highlights the role rs594445 in two psychiatric conditions and implies the presence of common genetic factors for these disorders.

钼辅因子硫化酶 (MOCOS) 是一种参与嘌呤代谢的酶。当前研究的目的是评估编码基因 (rs594445) 中单核苷酸多态性 (SNP) 在情绪障碍和甲基苯丙胺成瘾中的作用。

使用四引物对 200 名甲基苯丙胺成瘾者、85 名双相情感障碍 1 (BP1) 患者、78 名 BP2 患者、33 名重度抑郁症 (MDD) 患者和 200 名年龄/性别匹配的正常受试者进行基因分型扩增耐药突变系统（ARMS）-PCR技术。

rs594445 与共显性模型中的甲基苯丙胺成瘾相关 [A/A 与 C/C：OR (95% CI) = 0.466 (0.252–0.864)，磷-值 = 0.014；C/A 与 C/C：OR (95% CI) = 0.641 (0.418–0.981)，磷-值 = 0.04]。该 SNP 也与显性模型中的该特征相关 [OR (95% CI) = 0.591 (0.398–0.879)，磷-值 = 0.009]。rs594445 的 A 等位基因对甲基苯丙胺成瘾具有保护作用 [A vs C: OR (95% CI) = 0.645 (0.48–0.866),磷-值 = 0.004]。rs594445 与共显性模型中的 BP1 相关 [C/A 与 C/C：OR (95% CI) = 0.423 (0.230–0.778)，磷-值 = 0.005]。然而，这些关联在其他继承模型中是微不足道的。

最后，在任何遗传模型中，提到的 SNP 与 BP2 或 MDD 的风险之间没有显着关联。本项目强调 rs594445 在两种精神疾病中的作用，并暗示这些疾病存在共同的遗传因素。