Abstract

We optimize the procedure for synthesizing gold nanoshells for their use as a sensitive label in an immunochromatographic assay (ICA). An immunochromatographic test system is developed to visually determine the concentration of an early cardio marker, a heart-type fatty acid-binding protein (H-FABP). Visual detection yields the detection limit of the procedure with gold nanoshells to be more 50% lower than that of gold nanoparticles; it is 0.5 ng/mL for H-FABP.

中文翻译：

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二氧化硅基金纳米壳：免疫色谱分析法的合成与应用

摘要

我们优化了合成金纳米壳的程序，使其在免疫色谱分析（ICA）中用作敏感标记。开发了一种免疫色谱测试系统，以目视确定早期心脏标记物（一种心脏型脂肪酸结合蛋白（H-FABP））的浓度。目测可以发现金纳米壳比金纳米颗粒的检测限低50％。H-FABP为0.5 ng / mL。