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Silica-Based Gold Nanoshells: Synthesis and Application in Immunochromatographic Assay

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Moscow University Chemistry Bulletin Aims and scope

Abstract

We optimize the procedure for synthesizing gold nanoshells for their use as a sensitive label in an immunochromatographic assay (ICA). An immunochromatographic test system is developed to visually determine the concentration of an early cardio marker, a heart-type fatty acid-binding protein (H-FABP). Visual detection yields the detection limit of the procedure with gold nanoshells to be more 50% lower than that of gold nanoparticles; it is 0.5 ng/mL for H-FABP.

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ACKNOWLEDGMENTS

We used the equipment of the Training Center of Lithography and Microscopy of Moscow State University.

Funding

This work was supported as a part of the state budget topics “Research of Processes in Nanostructures and Devices Based on Them” (project no. 01201255519), “Studies of the Fundamental Physical Properties of Nanoelectronics” (project no. 01200309222), and “Molecular Design, Structural, and Functional Analysis and Regulation of Enzyme Systems, Cell Structures, and Bionanomaterials: Fundamental Principles and Applications in Technology, Medicine, and Environmental Protection” (project no. AAAA-A16-116052010081-5).

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, 119991, Moscow, Russia

    V. G. Grigorenko, I. P. Andreeva, G. V. Presnova, E. A. Yakovleva & A. P. Osipov

  2. Skobeltsyn Institute of Nuclear Physics, Moscow State University, 119991, Moscow, Russia

    D. E. Presnov

  3. Department of Physics, Quantum Technology Centre, Moscow State University, 119991, Moscow, Russia

    D. E. Presnov

Authors
  1. V. G. Grigorenko
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  2. I. P. Andreeva
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  3. G. V. Presnova
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  4. D. E. Presnov
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  5. E. A. Yakovleva
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  6. A. P. Osipov
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Corresponding author

Correspondence to V. G. Grigorenko.

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Translated by O. Zhukova

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Grigorenko, V.G., Andreeva, I.P., Presnova, G.V. et al. Silica-Based Gold Nanoshells: Synthesis and Application in Immunochromatographic Assay. Moscow Univ. Chem. Bull. 75, 207–212 (2020). https://doi.org/10.3103/S0027131420040021

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  • DOI: https://doi.org/10.3103/S0027131420040021

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