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Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma.
Nature Immunology ( IF 27.7 ) Pub Date : 2020-09-23 , DOI: 10.1038/s41590-020-0797-z
Hamida Hammad 1, 2 , Bart N Lambrecht 1, 2, 3
Affiliation  

The activation of the Notch4–Wnt–GDF15 axis in induced regulatory T (Treg cells) dampens their immunoregulatory function and turns them into TH2 and TH17 cytokine producers, allowing them to maintain ongoing allergic asthma.

中文翻译:

调节性 T 细胞中的 Wnt 和 Hippo 通路:哮喘中的一个缺口。

Notch4-Wnt-GDF15 轴在诱导调节性 T(Treg 细胞)中的激活减弱了它们的免疫调节功能,并将它们变成 TH2 和 TH17 细胞因子生产者,使它们能够维持持续的过敏性哮喘。
更新日期:2020-09-23
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