Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

ASTHMA

Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma

The activation of the Notch4–Wnt–GDF15 axis in induced regulatory T (Treg cells) dampens their immunoregulatory function and turns them into TH2 and TH17 cytokine producers, allowing them to maintain ongoing allergic asthma.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Notch4+ Treg cells contribute to TH2 immunity following exposure to allergens and air pollutants.

Debbie Maizels/Springer Nature

References

  1. Bailis, W. et al. Immunity 39, 148–159 (2013).

    Article  CAS  Google Scholar 

  2. Harb, H. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0777-3 (2020).

  3. Amsen, D. et al. Cell 117, 515–526 (2004).

    Article  CAS  Google Scholar 

  4. Tindemans, I. et al. J. Allergy Clin. Immunol. 140, 1079–1089 (2017).

    Article  CAS  Google Scholar 

  5. Xia, M., Harb, H., Saffari, A., Sioutas, C. & Chatila, T. A. J. Allergy Clin. Immunol. 142, 1243–1256.e17 (2018).

    Article  CAS  Google Scholar 

  6. Verhein, K. C. Environ. Health Perspect. 123, 799–805 (2015).

    Article  CAS  Google Scholar 

  7. Geng, J. Nat. Immunol. 18, 800–812 (2017); erratum 18, 1270 (2017).

  8. van Loosdregt, J. et al. Immunity 39, 298–310 (2013).

    Article  Google Scholar 

  9. Yu, Q. et al. Nat. Immunol. 10, 992–999 (2009).

    Article  CAS  Google Scholar 

  10. Rigas, D. J. Allergy Clin. Immunol. 139, 1468–1477.e2 (2017).

    Article  CAS  Google Scholar 

  11. Verhamme, F. M. Mucosal Immunol. 10, 1400–1411 (2017).

    Article  CAS  Google Scholar 

  12. Varelas, X. Dev. Cell 18, 579–591 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hamida Hammad.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hammad, H., Lambrecht, B.N. Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma. Nat Immunol 21, 1313–1314 (2020). https://doi.org/10.1038/s41590-020-0797-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-020-0797-z

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing