Human organoid models of the central nervous system, including the neural retina, are providing unprecedented opportunities to explore human neurodevelopment and neurodegeneration in controlled culture environments. In this Perspective, we discuss how the single-cell multi-omic toolkit has been used to identify features and limitations of brain and retina organoids and how these tools can be deployed to study congenital brain malformations and vision disorders in organoids. We also address how to improve brain and retina organoid protocols to revolutionize in vitro disease modeling.

中文翻译：

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使用类器官单细胞多组学解决神经发育和视力障碍

包括神经视网膜在内的中枢神经系统的人类类器官模型为探索人类在受控培养环境中的神经发育和神经变性提供了前所未有的机会。在本《观点》中，我们讨论了如何使用单细胞多组学工具包来识别脑和视网膜类器官的特征和局限性，以及如何将这些工具用于研究类动物中的先天性脑畸形和视力障碍。我们还解决了如何改善大脑和视网膜类器官协议以革新体外疾病建模。