Neuron
Volume 107, Issue 6, 23 September 2020, Pages 1000-1013
Journal home page for Neuron

Perspective
Resolving Neurodevelopmental and Vision Disorders Using Organoid Single-Cell Multi-omics

https://doi.org/10.1016/j.neuron.2020.09.001Get rights and content
Under an Elsevier user license
open archive

Summary

Human organoid models of the central nervous system, including the neural retina, are providing unprecedented opportunities to explore human neurodevelopment and neurodegeneration in controlled culture environments. In this Perspective, we discuss how the single-cell multi-omic toolkit has been used to identify features and limitations of brain and retina organoids and how these tools can be deployed to study congenital brain malformations and vision disorders in organoids. We also address how to improve brain and retina organoid protocols to revolutionize in vitro disease modeling.

Keywords

stem cells
cerebral organoids
retinal organoids
single-cell genomics
disease modeling

Cited by (0)