The significant destructive changes in ultrastructure of hepatocytes from laboratory mice kept in different vivariums in Moscow and fed with dry laboratory animal diets acquired from different domestic manufacturers that were not standardized for initial products were demonstrated using electron microscopy. Furthermore, disruption in the ultrastructure of liver parenchymal cells occurred regardless of the animal status (SPF or conventional), conditions of various vivariums, as well as the feed manufacturer. At the same time, studies on ultrastructure of liver hepatocytes from mice kept in the Charles River Laboratory facilities in Germany and fed with the Altromin Spezialfutter laboratory animal diet (GmbH & Co., Germany) that was produced using quality control of ingredients did not reveal destructive changes in the internal ultrastructure of hepatocytes. However, if these mice were later fed with the food produced in local manufactures, changes in the structure of liver cells developed after 2 months. Thus, feeding with dry diet from the domestic producers of an unspecified composition causes significant changes in the ultrastructure of hepatocytes in control animals, reflecting the development of some pathological processes in the body.

中文翻译：

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喂食标准干实验动物饮食的实验小鼠肝细胞的超微结构

使用电子显微镜证明了实验室小鼠肝细胞超微结构的显着破坏性变化，这些小鼠饲养在莫斯科的不同动物饲养箱中，并从不同的国内制造商处获得的未标准化初始产品的干燥实验室动物饲料喂养。此外，无论动物状态（SPF 或常规）、各种饲养场的条件以及饲料制造商如何，都会发生肝实质细胞超微结构的破坏。同时，对来自德国查尔斯河实验室设施并饲喂 Altromin Spezialfutter 实验室动物饲料（GmbH & Co., 使用成分质量控制生产的德国）没有显示肝细胞内部超微结构的破坏性变化。然而，如果这些老鼠后来用当地制造的食物喂养，2个月后肝细胞的结构就会发生变化。因此，用来自国内生产商的未指定成分的干饲料喂养导致对照动物肝细胞超微结构的显着变化，反映了体内某些病理过程的发展。