Higher body mass index (BMI) is associated with osteoarthritis (OA) in both weight-bearing and non-weight-bearing joints, suggesting a link between OA and poor metabolic health beyond mechanical loading. This risk may be influenced by systemic factors accompanying BMI. Fluctuations in concentrations of metabolites may mark or even contribute to development of OA. This study explores the association of metabolites with radiographic knee/hip OA prevalence and progression. A ¹H-NMR-metabolomics assay was performed on plasma samples of 1564 cases for prevalent OA and 2,125 controls collected from the Rotterdam Study, CHECK, GARP/NORREF and LUMC-arthroplasty cohorts. OA prevalence and 5 to 10 year progression was assessed by means of Kellgren-Lawrence (KL) score and the OARSI-atlas. End-stage knee/hip OA (TJA) was defined as indication for arthroplasty surgery. Controls did not have OA at baseline or follow-up. Principal component analysis of 227 metabolites demonstrated 23 factors, of which 19 remained interpretable after quality-control. Associations of factor scores with OA definitions were investigated with logistic regression. Fatty acids chain length (FALen), which was included in two factors which associated with TJA, was individually associated with both overall OA as well as TJA. Increased Fatty Acid chain Length is associated with OA.

较高的体重指数 (BMI) 与负重和非负重关节的骨关节炎 (OA) 相关，表明 OA 与机械负荷以外的不良代谢健康之间存在联系。这种风险可能受到伴随 BMI 的全身性因素的影响。代谢物浓度的波动可能标志着甚至有助于 OA 的发展。本研究探讨代谢物与放射学膝/髋 OA 患病率和进展的关联。一个¹对从鹿特丹研究、CHECK、GARP/NORREF 和 LUMC 关节成形术队列收集的 1564 例流行 OA 和 2125 例对照的血浆样本进行了 H-NMR 代谢组学分析。通过凯尔格伦-劳伦斯 (KL) 评分和 OARSI-atlas 评估 OA 患病率和 5 至 10 年的进展。终末期膝关节/髋关节 OA (TJA) 被定义为关节置换手术的指征。对照组在基线或随访时没有 OA。227 种代谢物的主成分分析显示了 23 个因素，其中 19 个在质量控制后仍可解释。用逻辑回归研究了因素评分与 OA 定义的关联。脂肪酸链长 (FALen) 包含在与 TJA 相关的两个因素中，分别与整体 OA 和 TJA 相关。