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MRI-based Parcellation and Morphometry of the Individual Rhesus Monkey Brain: the macaque Harvard-Oxford Atlas (mHOA), a translational system referencing a standardized ontology.
Brain Imaging and Behavior ( IF 2.4 ) Pub Date : 2020-09-22 , DOI: 10.1007/s11682-020-00357-9
R Jarrett Rushmore 1, 2, 3 , Sylvain Bouix 2 , Marek Kubicki 2, 3 , Yogesh Rathi 2, 3 , Douglas L Rosene 1 , Edward H Yeterian 2, 3, 4 , Nikos Makris 1, 2, 3
Affiliation  

Investigations of the rhesus monkey (Macaca mulatta) brain have shed light on the function and organization of the primate brain at a scale and resolution not yet possible in humans. A cornerstone of the linkage between non-human primate and human studies of the brain is magnetic resonance imaging, which allows for an association to be made between the detailed structural and physiological analysis of the non-human primate and that of the human brain. To further this end, we present a novel parcellation method and system for the rhesus monkey brain, referred to as the macaque Harvard-Oxford Atlas (mHOA), which is based on the human Harvard-Oxford Atlas (HOA) and grounded in an ontological and taxonomic framework. Consistent anatomical features were used to delimit and parcellate brain regions in the macaque, which were then categorized according to functional systems. This system of parcellation will be expanded with advances in technology and, like the HOA, will provide a framework upon which the results from other experimental studies (e.g., functional magnetic resonance imaging (fMRI), physiology, connectivity, graph theory) can be interpreted.



中文翻译:


基于 MRI 的恒河猴个体大脑分区和形态测量:猕猴哈佛-牛津图谱 (mHOA),一个引用标准化本体论的翻译系统。



对恒河猴( Macaca mulatta )大脑的研究揭示了灵长类动物大脑的功能和组织,其规模和分辨率在人类中尚无法实现。非人类灵长类动物和人类大脑研究之间联系的基石是磁共振成像,它允许在非人类灵长类动物和人类大脑的详细结构和生理分析之间建立关联。为了进一步实现这一目标,我们提出了一种针对恒河猴大脑的新颖的分割方法和系统,称为猕猴哈佛-牛津图集(mHOA),它基于人类哈佛-牛津图集(HOA)并基于本体论和分类框架。使用一致的解剖特征来界定和分割猕猴的大脑区域,然后根据功能系统对其进行分类。这种分割系统将随着技术的进步而扩展,并且像 HOA 一样,将提供一个框架,在此框架上可以解释其他实验研究(例如功能磁共振成像 (fMRI)、生理学、连接性、图论)的结果。

更新日期:2020-09-22
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