In this work, we report the synthesis of two new Yb(III)-based coordination polymers [Yb(Btca)(Idc)(H2O)]n (1, HBtca = 1H-benzo[d][1,2,3]triazole-5-carboxylic acid and H3Idc = 1H-imidazole-4,5-dicarboxylic acid) and [Yb2(Thz)3·8H2O)]·H2O (2, H2Thz = thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid) prepared under the solvothermal conditions using two heterodonor organic ligands. The two complexes are fully determined via single crystal X-ray diffraction along with the elemental analysis. Furthermore, the synergy effect of compounds 1 and 2 with seventy-flavor pearl pills on the cerebral ischemic events is evaluated in vivo. Firstly, the enzyme-linked immunosorbent assay (ELISA) is performed to measure the content of dopamine and 5-serotonin in the brain after treatment with compounds 1 and 2. Then, the reactive oxygen species (ROS) detection is conducted to determine the inhibitory effect of the compounds on the inflammatory level in the brain.

中文翻译：

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两种含 Yb(III) 的配位聚合物：通过调节单胺神经递质与七十味珍珠丸对脑缺血的结构洞察和协同效应

在这项工作中，我们报告了两种新的基于 Yb(III) 的配位聚合物 [Yb(Btca)(Idc)(H2O)]n (1, HBtca = 1H-benzo[d][1,2,3]三唑-5-羧酸和 H3Idc = 1H-咪唑-4,5-二羧酸) 和 [Yb2(Thz)3·8H2O)]·H2O (2, H2Thz = 噻唑并[5,4-d]噻唑-2, 5-二羧酸）在溶剂热条件下使用两个杂供体有机配体制备。这两种配合物完全通过单晶 X 射线衍射和元素分析确定。此外，在体内评价了化合物1和2与七十味珍珠丸对脑缺血事件的协同作用。首先，进行酶联免疫吸附试验 (ELISA) 以测量化合物 1 和 2 治疗后大脑中多巴胺和 5-羟色胺的含量。然后，