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TWO Yb(III)-CONTAINING COORDINATION POLYMERS: STRUCTURAL INSIGHTS AND SYNERGY EFFECT WITH SEVENTY-FLAVOR PEARL PILLS ON CEREBRAL ISCHEMIA BY REGULATING MONOAMINE NEUROTRANSMITTERS

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Abstract

In this work, we report the synthesis of two new Yb(III)-based coordination polymers [Yb(Btca)(Idc)(H2O)]n (1, HBtca = 1H-benzo[d][1,2,3]triazole-5-carboxylic acid and H3Idc = 1H-imidazole-4,5-dicarboxylic acid) and [Yb2(Thz)3·8H2O)]·H2O (2, H2Thz = thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid) prepared under the solvothermal conditions using two heterodonor organic ligands. The two complexes are fully determined via single crystal X-ray diffraction along with the elemental analysis. Furthermore, the synergy effect of compounds 1 and 2 with seventy-flavor pearl pills on the cerebral ischemic events is evaluated in vivo. Firstly, the enzyme-linked immunosorbent assay (ELISA) is performed to measure the content of dopamine and 5-serotonin in the brain after treatment with compounds 1 and 2. Then, the reactive oxygen species (ROS) detection is conducted to determine the inhibitory effect of the compounds on the inflammatory level in the brain.

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Funding

This work was supported by grants from Natural Science Foundation of Tibet (No. XZ 2018 ZR G-73).

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  1. School of Medicine, Xizang Minzu University, Xianyang, P. R. China

    H. Ma, H. Rong, J. -J. Zhang, J. -M. Shi & Z. -Q. Sun

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  1. H. Ma
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  2. H. Rong
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  3. J. -J. Zhang
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  5. Z. -Q. Sun
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Correspondence to Z. -Q. Sun.

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Ma, H., Rong, H., Zhang, J.J. et al. TWO Yb(III)-CONTAINING COORDINATION POLYMERS: STRUCTURAL INSIGHTS AND SYNERGY EFFECT WITH SEVENTY-FLAVOR PEARL PILLS ON CEREBRAL ISCHEMIA BY REGULATING MONOAMINE NEUROTRANSMITTERS. J Struct Chem 61, 1288–1295 (2020). https://doi.org/10.1134/S0022476620080156

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