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Chiral Symmetry Breaking in Large Peptide Systems
Origins of Life and Evolution of Biospheres ( IF 1.9 ) Pub Date : 2020-09-18 , DOI: 10.1007/s11084-020-09600-1
Konstantin K Konstantinov 1, 2 , Alisa F Konstantinova 1
Affiliation  

Chiral symmetry breaking in far from equilibrium systems with large number of amino acids and peptides, like a prebiotic Earth, was considered. It was shown that if organic catalysts were abundant, then effective averaging of enantioselectivity would prohibit any symmetry breaking in such systems. It was further argued that non-linear (catalytic) reactions must be very scarce (called the abundance parameter) and catalysts should work on small groups of similar reactions (called the similarity parameter) in order to chiral symmetry breaking have a chance to occur. Models with 20 amino acids and peptide lengths up to three were considered. It was shown that there are preferred ranges of abundance and similarity parameters where the symmetry breaking can occur in the models with catalytic synthesis / catalytic destruction / both catalytic synthesis and catalytic destruction. It was further shown that models with catalytic synthesis and catalytic destruction statistically result in a substantially higher percentage of the models where the symmetry breaking can occur in comparison to the models with just catalytic synthesis or catalytic destruction. It was also shown that when chiral symmetry breaking occurs, then concentrations of some amino acids, which collectively have some mutually beneficial properties, go up, whereas the concentrations of the ones, which don’t have such properties, go down. An open source code of the whole system was provided to ensure that the results can be checked, repeated, and extended further if needed.



中文翻译:

大型肽系统中的手性对称性破缺

人们考虑了手性对称性在远离平衡系统的情况下,具有大量氨基酸和肽,如生命起源前的地球。结果表明,如果有机催化剂丰富,那么对映选择性的有效平均将阻止此类系统中的任何对称性破缺。有人进一步认为,非线性(催化)反应必须非常稀缺(称为丰度参数),并且催化剂应该对一小群相似反应(称为相似性参数)起作用,以便手性对称性破缺有机会发生。考虑了具有 20 个氨基酸和肽长度最多为 3 个的模型。结果表明,在催化合成/催化破坏/催化合成和催化破坏模型中,存在对称性破缺可能发生的丰度和相似性参数的优选范围。进一步表明,与仅具有催化合成或催化破坏的模型相比,具有催化合成和催化破坏的模型在统计上导致发生对称性破缺的模型的百分比显着更高。研究还表明,当手性对称性破缺发生时,一些氨基酸(它们共同具有一些互利特性)的浓度会上升,而那些不具有这些特性的氨基酸的浓度则会下降。提供了整个系统的开源代码,以确保结果可以在需要时进行检查、重复和进一步扩展。

更新日期:2020-09-18
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