Abstract

Some new fused chromenopyrimidines have been synthesized and evaluated for their antimicrobial activity based on the precursor 4H-chromene-3-carbonitrile. Heterocyclization of 4H-chromene-3-carbonitrile derivative results in pyrimidine, pyrimidinone, pyrimidinedithione, and iminopyrimidine derivatives. Acetylated N-aminochromeno[2,3-d]pyrimidine derivative has been introduced into S_N2/heterocyclization reaction with formation of 2-substituted pyrimidinone derivatives. 4H-Chromene-3-carbonitrile propargylation followed by the “click reaction” has resulted in chromene linked 1,2,3-triazole. Some newly synthesized compounds demonstrate significant antimicrobial activity.

中文翻译：

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新型3 H -Chromeno [2,3-d]嘧啶衍生物的合成及抑菌活性

摘要

已经合成了一些新的稠合的嘧啶并嘧啶，并基于前体4 H-色烯-3-腈进行了抗菌活性评估。4 H-苯甲基-3-腈衍生物的杂环化产生嘧啶，嘧啶酮，嘧啶二硫酮和亚氨基嘧啶衍生物。乙酰化的N-氨基色素[2,3- d ]嘧啶衍生物已被引入S _N 2 /杂环化反应中，形成2-取代的嘧啶酮衍生物。4 H -Chromene-3-腈的炔丙基化反应以及随后的“点击反应”导致了与色烯相连的1,2,3-三唑。一些新合成的化合物显示出显着的抗菌活性。