Abstract
Some new fused chromenopyrimidines have been synthesized and evaluated for their antimicrobial activity based on the precursor 4H-chromene-3-carbonitrile. Heterocyclization of 4H-chromene-3-carbonitrile derivative results in pyrimidine, pyrimidinone, pyrimidinedithione, and iminopyrimidine derivatives. Acetylated N-aminochromeno[2,3-d]pyrimidine derivative has been introduced into SN2/heterocyclization reaction with formation of 2-substituted pyrimidinone derivatives. 4H-Chromene-3-carbonitrile propargylation followed by the “click reaction” has resulted in chromene linked 1,2,3-triazole. Some newly synthesized compounds demonstrate significant antimicrobial activity.
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Moustafa, A.H., Mohammed, S.M., El-Salam, E.A.A. et al. Synthesis and Antimicrobial Activity of New 3H-Chromeno[2,3-d]pyrimidine Derivatives. Russ J Gen Chem 90, 1566–1572 (2020). https://doi.org/10.1134/S1070363220080277
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DOI: https://doi.org/10.1134/S1070363220080277