Epsins are a family of adaptor proteins involved in clathrin-dependent endocytosis. In the vasculature, epsins 1 and 2 are functionally redundant members of this family that are expressed in the endothelial cells of blood vessels and the lymphatic system throughout development and adulthood. These proteins contain a number of peptide motifs that allow them to interact with lipid moieties and a variety of proteins. These interactions facilitate the regulation of a wide range of cell signaling pathways. In this review, we focus on the involvement of epsins 1 and 2 in controlling vascular endothelial growth factor receptor signaling in angiogenesis and lymphangiogenesis. We also discuss the therapeutic implications of understanding the molecular mechanisms of epsin-mediated regulation in diseases such as atherosclerosis and diabetes.

Epsins 是一类参与网格蛋白依赖性内吞作用的衔接蛋白。在脉管系统中，epsins 1 和 2 是该家族的功能冗余成员，它们在整个发育和成年期的血管内皮细胞和淋巴系统中表达。这些蛋白质包含许多肽基序，使它们能够与脂质部分和多种蛋白质相互作用。这些相互作用促进了多种细胞信号通路的调节。在这篇综述中，我们关注 epsins 1 和 2 在控制血管生成和淋巴管生成中的血管内皮生长因子受体信号传导中的作用。我们还讨论了了解 epsin 介导的调节在动脉粥样硬化和糖尿病等疾病中的分子机制的治疗意义。