The regioselective coupling of 2-arylquinazolinone C–H with aldehydes and benzyl alcohols under oxidative conditions,New Journal of Chemistry

当前位置： X-MOL 学术 › New J. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The regioselective coupling of 2-arylquinazolinone C–H with aldehydes and benzyl alcohols under oxidative conditions
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2020-09-14 , DOI: 10.1039/d0nj03721d
Umesh A. Kshirsagar _{1,

2,

3,

4,

5} , Deepali S. Waghmare _{4,

5,

6,

7} , Shrikant D. Tambe _{4,

5,

6,

7}

Affiliation

The direct and regioselective palladium-catalyzed dehydrogenative coupling of aldehydes and benzyl alcohols with 2-aryl-quinazolinone C–H endowed with a quinazolinone nucleus, which is one of the most fascinating and vital core units, as an inherent directing group under oxidative conditions was developed. This atom/step economic aroylation offers an attractive handle and a very green approach for highly convergent and diversity-oriented synthetic modifications and the construction of vital molecules of therapeutic interest.

中文翻译：

在氧化条件下2-芳基喹唑啉酮CH与醛和苯甲醇的区域选择性偶联

醛和苄醇与2-芳基-喹唑啉酮CH的直接和区域选择性的钯催化脱氢偶联，喹唑啉酮核是最引人入胜且至关重要的核心单元之一，它是氧化条件下固有的引导基团，它是发达。这种原子/步骤的经济芳基化为高度聚合和面向多样性的合成修饰和具有治疗意义的重要分子的构建提供了一种引人注目的处理方法和非常绿色的方法。

更新日期：2020-10-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11