Issue 39, 2020
From the journal:

New Journal of Chemistry

The regioselective coupling of 2-arylquinazolinone C–H with aldehydes and benzyl alcohols under oxidative conditions†

Umesh A. Kshirsagar, ORCID logo *ab   Deepali S. Waghmareb  and  Shrikant D. Tambeb  

* Corresponding authors

a Discipline of Chemistry, Indian Institute of Technology Indore, Indore, India
E-mail: uakshirsagar@iiti.ac.in

b Department of Chemistry, Savitribai Phule Pune University, Pune, India

Abstract

The direct and regioselective palladium-catalyzed dehydrogenative coupling of aldehydes and benzyl alcohols with 2-aryl-quinazolinone C–H endowed with a quinazolinone nucleus, which is one of the most fascinating and vital core units, as an inherent directing group under oxidative conditions was developed. This atom/step economic aroylation offers an attractive handle and a very green approach for highly convergent and diversity-oriented synthetic modifications and the construction of vital molecules of therapeutic interest.

Graphical abstract: The regioselective coupling of 2-arylquinazolinone C–H with aldehydes and benzyl alcohols under oxidative conditions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0NJ03721D
Article type
Letter
Submitted
23 Jul 2020
Accepted
09 Sep 2020
First published
14 Sep 2020

New J. Chem., 2020,44, 16697-16701

Permissions

Request permissions

The regioselective coupling of 2-arylquinazolinone C–H with aldehydes and benzyl alcohols under oxidative conditions

U. A. Kshirsagar, D. S. Waghmare and S. D. Tambe, New J. Chem., 2020, 44, 16697 DOI: 10.1039/D0NJ03721D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements