Under solvothermal reaction conditions, two new Mn(II)-containing meta-organic frameworks (MOFs) having the chemical formula of [Mn(bda) (L)·0.5H₂O]_n (1) and [Mn(Hdda)₂(L)·4H₂O)]_n (2) were prepared via a mixed-ligand method using different aromatic dicarboxylic acids ligands (H₂bda = benzopheno-4,4-dicarboxylic acid, H₂dda = 1,2-diethyl ether-4,4′-dibenzoic acid) and the flexible 1,3-di(1 h-imidazol-1-yl)propane (L). Meanwhile, it is further demonstrated that complex 1 with excellent water stability can be used for a promising sensor for Fe³⁺ ions in aqueous solution, which has good selectivity and sensitivity. For the treatment of the alcohol-induced cerebellar atrophy, the accumulation of reactive oxygen species (ROS) in purkinje cells was evaluated by 2′,7′-dichlorofluorescin diacetate (DCFH-DA) assay. Besides, through real time reverse transcription-polymerase chain reaction (RT-PCR), the relative expression of ROS related gene in purkinje cells was detected.

在溶剂热反应条件下，两个具有化学式[Mn（bda）（L）·0.5H ₂ O] _n（1）和[Mn（Hdda）_2的新的含Mn（II）的超有机骨架（MOF）（L）·4H ₂ O）] _n（2）是通过混合配体方法使用不同的芳族二羧酸配体（H ₂ bda =苯甲酚-4,4-二羧酸，H ₂ dda = 1,2-二乙基）制备的醚-4,4'-二苯甲酸）和柔性1,3-二（1 h-咪唑-1-基）丙烷（L）。同时，进一步证明具有优异水稳定性的配合物1可以用于有前途的Fe ³⁺传感器。离子在水溶液中，具有良好的选择性和灵敏度。为了治疗酒精引起的小脑萎缩，通过2'，7'-二氯荧光素二乙酸（DCFH-DA）分析评估浦肯野细胞中活性氧（ROS）的积累。此外，通过实时逆转录-聚合酶链反应（RT-PCR），检测浦肯野细胞中ROS相关基因的相对表达。