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Two Mn(II)-Organic Frameworks: Selective Detection of Fe3+ Ion and Treatment Activity on Alcohol-Induced Cerebellar Atrophy By Reducing ROS Accumulation in Brain

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Abstract

Under solvothermal reaction conditions, two new Mn(II)-containing meta-organic frameworks (MOFs) having the chemical formula of [Mn(bda) (L)·0.5H2O]n (1) and [Mn(Hdda)2(L)·4H2O)]n (2) were prepared via a mixed-ligand method using different aromatic dicarboxylic acids ligands (H2bda = benzopheno-4,4-dicarboxylic acid, H2dda = 1,2-diethyl ether-4,4′-dibenzoic acid) and the flexible 1,3-di(1 h-imidazol-1-yl)propane (L). Meanwhile, it is further demonstrated that complex 1 with excellent water stability can be used for a promising sensor for Fe3+ ions in aqueous solution, which has good selectivity and sensitivity. For the treatment of the alcohol-induced cerebellar atrophy, the accumulation of reactive oxygen species (ROS) in purkinje cells was evaluated by 2′,7′-dichlorofluorescin diacetate (DCFH-DA) assay. Besides, through real time reverse transcription-polymerase chain reaction (RT-PCR), the relative expression of ROS related gene in purkinje cells was detected.

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Authors and Affiliations

  1. Department of Psychiatry, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China

    En-Jie Guan, Yan Xia & Jian Hu

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  1. En-Jie Guan
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  2. Yan Xia
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Correspondence to Jian Hu.

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Guan, EJ., Xia, Y. & Hu, J. Two Mn(II)-Organic Frameworks: Selective Detection of Fe3+ Ion and Treatment Activity on Alcohol-Induced Cerebellar Atrophy By Reducing ROS Accumulation in Brain. J Inorg Organomet Polym 31, 1015–1025 (2021). https://doi.org/10.1007/s10904-020-01732-1

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  • DOI: https://doi.org/10.1007/s10904-020-01732-1

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