In the present research, pH-sensitive interpenetrating polymeric network are prepared by interpenetration of two natural polysaccharides Moringa bark gum(MOG) and Carrageenan (CRG) by use of microwave irradiation as interpenetrating polymeric network (IPN) and characterized using fourier transform infrared spectroscopy(FTIR), x-ray diffraction (XRD), thermogravimetric studies (TGA) and 13C nuclear magnetic resonance (13C NMR) and the surface topography, indepth pore size as well as the interior architecture of the material were confirmed by scanning electron microscopy(SEM) and atomic force microscopy (AFM).The contact angle measurement by optical contact angle (OCA) indicated that the increase in MOG content increased the water retention capacity thereby maintaining the structural integrity of the polymeric network. The pH sensitivity at pH 2,7.4 & 9.2 and swelling studies helped in optimizing the best grade F7.The swelling kinetics of F7 followed second order kinetics. The biodegradability studies were done using soil burial method.The drug release from F7 was found to 88.17% for 8 h interval. The material proved to be hemocompatible. These studies indicated that MOG-CRG-IPN (F7) can be effectively used as an efficient controlled delivery device and can be explored as biomaterial.

在本研究中，pH敏感的互穿聚合物网络是通过将两种天然多糖辣木树皮胶（MOG）和角叉菜胶（CRG）通过微波辐照作为互穿聚合物网络（IPN）互穿而制备的，并使用傅里叶变换红外光谱（ FTIR），X射线衍射（XRD），热重分析（TGA）和13C核磁共振（13C NMR）以及材料的表面形貌，深度孔径以及内部结构通过扫描电子显微镜（SEM）得以确认通过光学接触角（OCA）进行的接触角测量表明，MOG含量的增加增加了保水能力，从而保持了聚合物网络的结构完整性。pH值为2,7时的pH敏感性。F7。F7的溶胀动力学遵循二级动力学。使用土壤掩埋法进行生物降解性研究，发现F7药物在8 h间隔内的释放率为88.17％。该材料被证明具有血液相容性。这些研究表明，MOG-CRG-IPN（F7）可以有效地用作有效的受控递送装置，并且可以作为生物材料进行研究。