Medium to long chain aliphatic amino alcohols have numerous applications in polymer-based industries. We herein report a biocatalytic reduction of amino fatty acids into corresponding amino alcohols using carboxylic acid reductase and E coli endogenous aldehyde reductases. Interestingly, employing this reaction in tandem with minimizing the hurdle of substrate insolubility, the biocatalysts successfully produced 5.76 mM 12-amino-1-dodecanol from 10 mM of corresponding 12-amino-dodecanoic acid. Finally, up to 9.17 mM of 8-amino-1-octanol was obtained in 24 h on a preparative scale reaction of 50 mM substrate. Graphic Abstract

中文翻译：

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羧酸还原酶从ω-氨基脂肪酸酶法合成脂肪族伯ω-氨基醇

中长链脂肪族氨基醇在基于聚合物的工业中有许多应用。我们在此报告了使用羧酸还原酶和大肠杆菌内源性醛还原酶将氨基脂肪酸生物催化还原为相应的氨基醇。有趣的是，利用该反应与最小化底物不溶性障碍的同时，生物催化剂成功地从 10 mM 的相应 12-氨基-十二烷酸中产生了 5.76 mM 12-氨基-1-十二烷醇。最后，在 50 mM 底物的制备规模反应中，在 24 小时内获得了高达 9.17 mM 的 8-氨基-1-辛醇。图形摘要