Abstract

Reactions of Cr, Mo, W, and Fe metal carbonyls with potentially heptadentate (S₃N₄) tripodal Schiff base ligand, (thio)₃tren, have been studied. The Schiff base (thio)₃tren has been prepared by condensation of thiophene-2-carboxaldehyde with tris(2-aminoethyl)amine. The Schiff base and its metal complexes have been characterized by IR, UV-Vis, ¹H and ¹³C NMR spectra, TGA, and elemental analysis. According to the spectroscopic data, (thio)₃tren is coordinated to the metal centers as a potentially heptadentate ligand. The products have been tested in vitro against the bacterial species, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus cereus by the disc diffusion and micro-broth dilution methods, and characterized by antibacterial activity higher than that of the ligand. The lowest MIC was determined for Fe complex against Bacillus cereus and the highest for Mo complex against Escherichia coli.

中文翻译：

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具有潜在七足（S 3 N 4）三脚架席夫碱配体的新型Cr，Mo，W和Fe金属配合物：合成，表征和抗菌活性

摘要

已研究了Cr，Mo，W和Fe金属羰基与潜在的七齿（S ₃ N ₄）三脚架席夫碱配体（thio）₃ tren的反应。Schiff碱（硫代）₃ tren已经通过噻吩-2-甲醛与三（2-氨基乙基）胺的缩合制备。Schiff碱及其金属配合物已通过IR，UV-Vis，¹ H和¹³ C NMR光谱，TGA和元素分析进行​​了表征。根据光谱数据，（硫）₃ tren作为潜在的七齿配体与金属中心配位。产品已针对细菌进行了体外测试，金黄色葡萄球菌，大肠杆菌，铜绿假单胞菌和蜡状芽孢杆菌采用圆盘扩散法和微肉汤稀释法，其抗菌活性高于配体。最低的MIC被确定为对蜡状芽孢杆菌的铁复合物，最高的对大肠杆菌的钼复合物。