AIDS/HIV is a serious life-threatening and public health problem that urges for new antiviral drugs to control. A bis-indole alkaloid voacamine has been isolated from Voacanga africana Stapf. In this study, voacamine 1H and 13C chemical shift assignments were redetermined using 1D and 2D NMR; 1H NMR and 13C NMR chemical shifts were accurately assigned. Absolute configuration was confirmed by single-crystal X-ray diffraction analysis with Cu Kα radiation, and in vitro antiviral activity against HIV via effecting the binding affinity with gp120 based on SPRi experiment was testified. This study supports the potential value of voacamine as a natural agent against AIDS/HIV.

中文翻译：

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基于 SPRi 实验的 Voacanga Africana Stapf Voacamine 的体外抗 HIV 作用

AIDS/HIV 是一个严重的威胁生命的公共健康问题，迫切需要新的抗病毒药物加以控制。已从 Voacanga Africana Stapf 中分离出双吲哚生物碱 voacamine。在本研究中，使用 1D 和 2D NMR 重新确定了 voacamine 1H 和 13C 化学位移分配；1H NMR 和 13C NMR 化学位移被准确指定。通过Cu Kα辐射的单晶X射线衍射分析证实了绝对构型，并证明了基于SPRi实验通过影响与gp120的结合亲和力对HIV的体外抗病毒活性。这项研究支持伏阿卡明作为抗艾滋病/艾滋病毒的天然药物的潜在价值。