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In Vitro Anti-HIV Effect of Voacamine from Voacanga africana Stapf Based on the SPRi Experiment

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Abstract

AIDS/HIV is a serious life-threatening and public health problem that urges for new antiviral drugs to control. A bis-indole alkaloid voacamine has been isolated from Voacanga africana Stapf. In this study, voacamine 1H and 13C chemical shift assignments were redetermined using 1D and 2D NMR; 1H NMR and 13C NMR chemical shifts were accurately assigned. Absolute configuration was confirmed by single-crystal X-ray diffraction analysis with Cu Kα radiation, and in vitro antiviral activity against HIV via effecting the binding affinity with gp120 based on SPRi experiment was testified. This study supports the potential value of voacamine as a natural agent against AIDS/HIV.

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Funding

This research was supported by the National Natural Science Foundation of China (no. 81703693; 81603537), Xing Lin Scholar Fund Project of TCM (no. QNXZ2018009), Youth Science and Technology Innovative Research Team Fund Project of Sichuan (grant no. 2016TD0006), Key Fund Project for Education Department of Sichuan (grant no. 17ZA161), and Science and Technology Development Fund of Chengdu University of TCM (grant no. ZRQN1563).

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Correspondence to Y. H. Chen or Y. Deng.

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This article does not contain any studies involving human participants performed by any of the authors and does not contain any studies involving animals performed by any of the authors.

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Authors declare there are no conflicts of interests.

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The authors contributed equally to the work.

Corresponding author: e-mail: tcmresearcher@163.com.

Corresponding author: e-mail: dengyun2000@hotmail.com.

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Li, H.X., Liu, R.Q., Zhang, H.M. et al. In Vitro Anti-HIV Effect of Voacamine from Voacanga africana Stapf Based on the SPRi Experiment. Russ J Bioorg Chem 46, 306–311 (2020). https://doi.org/10.1134/S1068162020030115

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  • DOI: https://doi.org/10.1134/S1068162020030115

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