Abstract

A new method has been proposed for the synthesis of pyranopyrimidinone and xanthene derivatives using zinc oxide–starch nanocomposite as catalyst under microwave irradiation. The ZnO–starch nanocomposite was characterized by X-ray diffraction and scanning electron microscopy data, and the size of the ZnO-starch nanocomposite particles was estimated at 70–90 nm. The catalyst was used in the three-component condensation of aromatic aldehydes with barbituric acid and malononitrile and the 1:2 condensation of aromatic aldehydes with naphthalen-2-ol to obtain pyranopyrimidinone and xanthene derivatives, respectively. The catalyst can be reused several times without loss of catalytic activity. The proposed procedure utilizes affordable and inexpensive materials, provides excellent yields in short reaction time, and is eco-friendly, which makes it more economic than conventional methods. The antibacterial activity of the synthesized compounds was evaluated against M. luteus and P. aeruginosa.

中文翻译：

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淀粉上浸渍的纳米ZnO-一种高效的多相生物基催化剂，用于一锅合成吡喃嘧啶酮和an吨衍生物作为潜在的抗菌剂

摘要

已经提出了一种新方法，以氧化锌-淀粉纳米复合材料为催化剂，在微波辐射下合成吡喃并嘧啶酮和one吨衍生物。ZnO-淀粉纳米复合材料的特征在于X射线衍射和扫描电子显微镜数据，并且ZnO-淀粉纳米复合材料颗粒的大小估计为70-90 nm。该催化剂用于芳香醛与巴比妥酸和丙二腈的三组分缩合，以及芳香醛与萘-2-醇的1：2缩合，分别得到吡喃并嘧啶酮和an吨衍生物。催化剂可以重复使用几次，而不会损失催化活性。拟议的程序利用经济实惠的材料，在短的反应时间内提供了优异的收率，并且对环境友好，这使其比传统方法更经济。评估了合成化合物的抗菌活性黄麻和铜绿假单胞菌。