The present study was conducted to investigate the cytotoxicity and genotoxicity induced by abamectin pesticide in Allium cepa L. bulbs. Following 72-h exposure to different doses (0.025 ml/L, 0.050 ml/L, and 0.100 ml/L) of abamectin, growth level, micronuclei abundance, mitotic index, chromosomal aberrations, malondialdehyde content, meristematic cell damages, and total activities of superoxide dismutase and catalase were explored. The results revealed that all concentrations of abamectin were capable of inducing significant and dose-dependent changes in all parameters. Increasing doses of abamectin caused remarkable decreases in germination ratio, weight gain, and root elongation. Due to abamectin-induced genotoxicity, the mitotic index declined, while chromosomal abnormalities listed as micronucleus, fragment, sticky chromosome, unequal distribution of chromatin, bridge, vacuole nucleus, nucleus damage, and multipolar anaphase. Depending on the oxidative stress caused by abamectin administration, the total activities of superoxide dismutase and catalase enzymes increased significantly along with the malondialdehyde content. Indistinct transmission tissue, epidermis cell deformation and flattened cell nucleus were the meristematic cell damages in pesticide-applied groups. Findings of the present study revealed that abamectin is a risky pesticide with a variety of cytotoxic and genotoxic effects in non-targeted organisms. A. cepa is a promising material for biomonitoring the toxicity of abamectin.

中文翻译：

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阿维菌素农药对洋葱的细胞毒性和遗传毒性的研究。

本研究旨在调查阿维菌素农药对洋葱鳞茎的细胞毒性和遗传毒性。在暴露于不同剂量（0.025 ml / L，0.050 ml / L和0.100 ml / L）的阿维菌素，生长水平，微核丰度，有丝分裂指数，染色体畸变，丙二醛含量，分生细胞损伤和总活动72小时后探索了超氧化物歧化酶和过氧化氢酶的组成。结果表明，所有浓度的阿维菌素都能够诱导所有参数的显着且剂量依赖性变化。阿维菌素剂量的增加导致发芽率，增重和根伸长显着下降。由于阿维菌素诱导的遗传毒性，有丝分裂指数下降，而染色体异常列为微核，片段，粘性染色体，染色质，桥，液泡核，核损伤和多极后期的分布不均。取决于由阿维菌素给药引起的氧化应激，超氧化物歧化酶和过氧化氢酶的总活性与丙二醛含量一起显着增加。在施用农药的组中，传播组织不清楚，表皮细胞变形和细胞核扁平是分生细胞损伤。本研究的发现表明，阿维菌素是一种危险的农药，在非目标生物中具有多种细胞毒性和遗传毒性作用。洋葱曲霉是用于生物监测阿维菌素毒性的一种有前途的材料。超氧化物歧化酶和过氧化氢酶的总活性随丙二醛含量的增加而显着增加。在施用农药的组中，传播组织不清楚，表皮细胞变形和细胞核扁平是分生细胞损伤。本研究的发现表明，阿维菌素是一种危险的农药，在非目标生物中具有多种细胞毒性和遗传毒性作用。洋葱曲霉是用于生物监测阿维菌素毒性的一种有前途的材料。超氧化物歧化酶和过氧化氢酶的总活性随丙二醛含量的增加而显着增加。在施用农药的组中，传播组织不清楚，表皮细胞变形和细胞核扁平是分生细胞损伤。本研究的发现表明，阿维菌素是一种危险的农药，在非目标生物中具有多种细胞毒性和遗传毒性作用。洋葱曲霉是用于生物监测阿维菌素毒性的一种有前途的材料。本研究的发现表明，阿维菌素是一种危险的农药，在非目标生物中具有多种细胞毒性和遗传毒性作用。洋葱曲霉是用于生物监测阿维菌素毒性的一种有前途的材料。本研究的发现表明，阿维菌素是一种危险的农药，在非目标生物中具有多种细胞毒性和遗传毒性作用。洋葱曲霉是用于生物监测阿维菌素毒性的一种有前途的材料。