Occupational exposure to heavy metals like lead and cadmium causes a wide range of biological effects and may elevate the risk of genetic damage. Heavy metal toxicity is now becoming a significant public health problem. There are many discrepancies in the results of the studies on the genotoxicity of heavy metals. Therefore, the study aimed to estimate lead, cadmium, and 8-OHdG levels (8-hydroxy-2-deoxyguanosine) and expression of DNA repair gene OGG1 (8-oxoguanine DNA glycosylase 1) in occupationally heavy metal exposed workers. The study comprised 100 workers, occupationally exposed to lead and cadmium from different factories and 100 controls without history of metal exposure. The lead and cadmium mean ± SD were 5.69 ± 12.07 µg/dL and 3.44 ± 1.33 µg/L in the cases and 1.27 ± 1.10 µg/dL and 1.07 ± 0.67 µg/L in the controls. The 8-OHdG concentration was significantly higher in the cases than the controls. Cadmium showed a significant positive correlation with 8-OHdG in the cases. The expression of OGG1 was significantly down-regulated in the cases compared to the controls. Lead levels did not show any significant correlation with OGG1, whereas cadmium level had a significant positive correlation with OGG1 in the cases. To conclude, the exposure to heavy metals is associated with increased oxidative DNA damage and impaired expression of the DNA repair gene, OGG1.

中文翻译：

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职业暴露工人的血铅和镉水平及其对DNA损伤和修复标志物的影响。

职业接触铅和镉等重金属会导致广泛的生物学影响，并可能增加遗传损害的风险。重金属毒性现在正成为一个重大的公共卫生问题。关于重金属的遗传毒性的研究结果存在许多差异。因此，该研究旨在估计铅，镉和8-OHdG水平（8-羟基-2-脱氧鸟苷）以及DNA修复基因OGG1（8-氧代鸟嘌呤DNA糖基化酶1）在重金属暴露工人中的表达。这项研究包括100名工人，这些工人职业暴露于不同工厂的铅和镉，以及100名没有金属暴露史的对照。铅和镉的平均值±标准偏差分别为5.69±12.07 µg / dL和3.44±1.33 µg / L，对照组为1.27±1.10 µg / dL和1.07±0.67 µg / L。在这种情况下，8-OHdG的浓度明显高于对照组。在这些案例中，镉与8-OHdG呈显着正相关。与对照组相比，OGG1的表达明显下调。铅水平与OGG1没有显着相关，而镉水平与OGG1有显着正相关。总而言之，暴露于重金属与增加的氧化DNA损伤和DNA修复基因OGG1的表达受损有关。而镉含量与OGG1呈显着正相关。总而言之，暴露于重金属与增加的氧化DNA损伤和DNA修复基因OGG1的表达受损有关。而镉含量与OGG1呈显着正相关。总而言之，暴露于重金属与增加的氧化DNA损伤和DNA修复基因OGG1的表达受损有关。