To investigate functional connectivity (FC) changes in end-stage renal disease (ESRD) patients with and without cognitive impairment (CI) by using resting-state functional magnetic resonance imaging (rs-fMRI). Twenty-three ESRD patients with CI, 22 ESRD patients with non-CI (NCI) and 23 matched healthy controls (HC) were included. Rs-fMRI scans were performed in all subjects. Full-range, long-range, and short-range FC defined voxel-wise based degree centrality (DC) and seed based FC were computed and contrasted among the groups. Compared with HC, the DC value of short functional connectivity (SFC), in ESRD patients have increased on the left supramarginal gyrus, while it reduced on the left insula and right postcentral gyrus in CI and decreased on the right precentral gyrus in NCI. Compared with NCI, the DC value of LFC in CI increased on the left fusiform gyrus, while the DC value of short functional connectivity (SFC) increased on the left middle orbital gyrus. In the seed-based FC analyses, the CI showed significantly decreased FC between the left insula and bilateral middle temporal gyrus, between the left fusiform gyrus and the right hippocampus, and between the left postcentral gyrus and the right parahippocampus compared to HC; the CI showed significantly increased FC between the left precuneus and the left fusiform gyrus, between the left postcentral gyrus and the right precuneus compared with NCI. Positive correlations were found between DC values on the right superior frontal gyrus and LDL and BDST, and between MoCA and the DC values on the left insula and the left postcentral gyrus. The altered degree centrality may serve as early biomarkers for CI in ESRD patients.

通过使用静止状态功能磁共振成像（rs-fMRI），研究有无认知障碍（CI）的终末期肾病（ESRD）患者的功能连接性（FC）变化。纳入了23例具有CI的ESRD患者，22例非CI（NCI）的ESRD患者和23个匹配的健康对照（HC）。在所有受试者中进行Rs-fMRI扫描。计算各组之间的全范围，远程和短程FC定义的基于体素的度中心度（DC）和基于种子的FC。与HC相比，ESRD患者的短功能连接（DC）的DC值在CI的左上颌上回增加，而在CI的左岛和右中后回减少，而在NCI的右中前回减少。与NCI相比，CI的LFC的DC值在左梭状回中增加，而短功能连接（SFC）的DC值在左中眶回中增加。在基于种子的FC分析中，与HC相比，CI显示左岛和双侧颞中回之间，梭形回和右海马之间以及左中后回和右海马之间的FC显着降低。与NCI相比，CI显示左前突和左梭状回之间，左中后回和右突前之间的FC显着增加。在右上额额回与LDL和BDST之间的DC值之间以及MoCA与在左岛和左中后回的DC值之间存在正相关。