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Abnormal degree centrality in end-stage renal disease (ESRD) patients with cognitive impairment: a resting-state functional MRI study

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Abstract

To investigate functional connectivity (FC) changes in end-stage renal disease (ESRD) patients with and without cognitive impairment (CI) by using resting-state functional magnetic resonance imaging (rs-fMRI). Twenty-three ESRD patients with CI, 22 ESRD patients with non-CI (NCI) and 23 matched healthy controls (HC) were included. Rs-fMRI scans were performed in all subjects. Full-range, long-range, and short-range FC defined voxel-wise based degree centrality (DC) and seed based FC were computed and contrasted among the groups. Compared with HC, the DC value of short functional connectivity (SFC), in ESRD patients have increased on the left supramarginal gyrus, while it reduced on the left insula and right postcentral gyrus in CI and decreased on the right precentral gyrus in NCI. Compared with NCI, the DC value of LFC in CI increased on the left fusiform gyrus, while the DC value of short functional connectivity (SFC) increased on the left middle orbital gyrus. In the seed-based FC analyses, the CI showed significantly decreased FC between the left insula and bilateral middle temporal gyrus, between the left fusiform gyrus and the right hippocampus, and between the left postcentral gyrus and the right parahippocampus compared to HC; the CI showed significantly increased FC between the left precuneus and the left fusiform gyrus, between the left postcentral gyrus and the right precuneus compared with NCI. Positive correlations were found between DC values on the right superior frontal gyrus and LDL and BDST, and between MoCA and the DC values on the left insula and the left postcentral gyrus. The altered degree centrality may serve as early biomarkers for CI in ESRD patients.

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Funding

This study has been supported by the National Natural Science Foundation of China (under Grant Nos. 81,771,819 and 81,571,734), National key research and development plan of China (Project 2017YFC0108803), Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund (Projects znpy2017048, znpy20160057 and znpy2017044), and the Fundamental Research Funds for the Central Universities (Projects 2042017kf0284 and 2,016,060,605,100,525). We thank all members of the Departments of Nephrology and Radiology at Zhongnan Hospital of Wuhan University for conducting this study as well as all participants for their good collaboration.

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  1. Peina Chen and Runyue Hu contributed equally to this work.

Authors and Affiliations

  1. Departments of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

    Peina Chen, Meng Peng, Qianqian Jiang & Xiaoyan Wu

  2. Department of Nephrology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou, China

    Peina Chen

  3. Departments of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

    Runyue Hu, Lei Gao, Baolin Wu & Haibo Xu

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  1. Peina Chen
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Correspondence to Xiaoyan Wu or Haibo Xu.

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This study was approved by the Ethics Committee of the Zhongnan Hospital of Wuhan University, and written informed consent was obtained from all participants prior to the experiment.

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Chen, P., Hu, R., Gao, L. et al. Abnormal degree centrality in end-stage renal disease (ESRD) patients with cognitive impairment: a resting-state functional MRI study. Brain Imaging and Behavior 15, 1170–1180 (2021). https://doi.org/10.1007/s11682-020-00317-3

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