Many natural substances are efficient in vitro and in vivo for the treatment of various disorders. However, treatment is often limited by their low bioavailability, water solubility and permeation. As a consequence, drugs are administered frequently and in large doses. There is therefore a need for techniques to enhance the solubility, permeability and the stability. Here, we review methods to improve solubility using particle engineering, complexation, solid dispersion, solubilization, chemical modifications and use of nanocarriers.

中文翻译：

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改善天然治疗性药物溶解度的方法

许多天然物质在体外和体内对于各种疾病的治疗都是有效的。然而，治疗常常受到其低生物利用度，水溶性和渗透性的限制。结果，药物经常以大剂量给药。因此，需要增强溶解度，渗透性和稳定性的技术。在这里，我们回顾了使用颗粒工程，络合，固体分散，增溶，化学修饰和纳米载体的使用来提高溶解度的方法。