Potentiometric detection of glucose based on oligomerization with a diboronic acid using polycation as an indicator.,Analytical Methods

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Potentiometric detection of glucose based on oligomerization with a diboronic acid using polycation as an indicator.
Analytical Methods ( IF 2.7 ) Pub Date : 2020-09-08 , DOI: 10.1039/d0ay01399d
Long Li ₁ , Ying Li , Wei Qin , Yi Qian

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A novel potentiometric sensor for D-glucose (Glu) using 4,4′-biphenyldiboronic acid as a receptor and polyion (poly-N-(3-aminopropyl)methacrylamide, PAPMA) as an indicator is described. The diboronic acid condenses with Glu via its two cis-diol units to form cyclic or linear oligomeric polyanions which can interact electrostatically with PAPMA, thus efficiently decreasing its potentiometric response on a polycation-sensitive membrane electrode. Although D-fructose (Fru), D-galactose (Gal) and D-mannose (Man) show even higher binding affinities to the diboronic acid as compared to Glu, these monosaccharides with only one cis-diol unit cannot oligomerize with the receptor, which efficiently excludes the interferences from the Glu's stereoisomers. The results obtained from blood sample analysis indicate that the proposed sensor is promising for detection of Glu in real-world applications.

中文翻译：

使用聚阳离子作为指示剂，通过与二硼酸的低聚反应，电位检测葡萄糖。

描述了一种新型的D-葡萄糖（Glu）电位传感器，该传感器使用4,4'-联苯二硼酸作为受体，并使用聚离子（聚-N-（3-氨基丙基）甲基丙烯酰胺，PAPMA）作为指示剂。二硼酸通过其两个顺式-二醇单元与Glu缩合，形成可以与PAPMA发生静电相互作用的环状或线性低聚聚阴离子，从而有效降低了它在聚阳离子敏感膜电极上的电位响应。尽管与Glu相比，D-果糖（Fru），D-半乳糖（Gal）和D-甘露糖（Man）对二硼酸的结合亲和力更高，但这些单糖仅具有一个顺式-二醇单元不能与受体低聚，从而有效排除了Glu立体异构体的干扰。从血液样本分析中获得的结果表明，该传感器有望在实际应用中检测Glu。

更新日期：2020-09-24

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