Issue 36, 2020
From the journal:

Analytical Methods

Potentiometric detection of glucose based on oligomerization with a diboronic acid using polycation as an indicator†

Long Li, ORCID logo *a   Ying Li,a   Wei Qin*bc  and  Yi Qiand  

* Corresponding authors

a College of Environment and Safety Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
E-mail: lilongyln@yeah.net
Tel: +86 532 84022020

b Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Shandong 266237, P. R. China

c Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Provincial Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai, Shandong 264003, P. R. China
E-mail: wqin@yic.ac.cn
Tel: +86 535 2109156

d College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Abstract

A novel potentiometric sensor for D-glucose (Glu) using 4,4′-biphenyldiboronic acid as a receptor and polyion (poly-N-(3-aminopropyl)methacrylamide, PAPMA) as an indicator is described. The diboronic acid condenses with Glu via its two cis-diol units to form cyclic or linear oligomeric polyanions which can interact electrostatically with PAPMA, thus efficiently decreasing its potentiometric response on a polycation-sensitive membrane electrode. Although D-fructose (Fru), D-galactose (Gal) and D-mannose (Man) show even higher binding affinities to the diboronic acid as compared to Glu, these monosaccharides with only one cis-diol unit cannot oligomerize with the receptor, which efficiently excludes the interferences from the Glu's stereoisomers. The results obtained from blood sample analysis indicate that the proposed sensor is promising for detection of Glu in real-world applications.

Graphical abstract: Potentiometric detection of glucose based on oligomerization with a diboronic acid using polycation as an indicator

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Supplementary files

Article information

DOI
https://doi.org/10.1039/D0AY01399D
Article type
Communication
Submitted
21 Jul 2020
Accepted
07 Sep 2020
First published
08 Sep 2020

Anal. Methods, 2020,12, 4422-4428

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Potentiometric detection of glucose based on oligomerization with a diboronic acid using polycation as an indicator

L. Li, Y. Li, W. Qin and Y. Qian, Anal. Methods, 2020, 12, 4422 DOI: 10.1039/D0AY01399D

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