Papillomaviruses (PVs) are an extremely large group of viruses that cause skin and mucosa infections in humans and various animals. In roe deer and red deer, most PVs belong to the Deltapapillomavirus genus and cause neoplastic changes that are generally described as fibropapillomas. Despite the wide distribution of roe and red deer throughout Europe and beyond, the data in the scientific literature regarding the widespread distribution of PVs and the genetic variability of PV genomes in these species are rather scarce. This study describes cutaneous fibropapillomatosis cases in roe and red deer with clinical manifestations that are typical of infections with PVs. In all cases, the presence of PV DNA was confirmed using PCR, followed by Sanger sequencing of the partial L1 gene. The complete PV genomes were determined in all the investigated samples using next-generation sequencing technology, revealing infections of roe deer with the CcaPV1-type and red deer with the CePV1v-type variant. A comparison of the complete CcaPV1-type and CePV1v-type variant genome sequences reported here with already available complete genome sequences in GenBank revealed their great genetic stability across time and space.

中文翻译：

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游离Ro和红鹿皮纤维状乳头瘤病的综合研究：从临床表现到乳头瘤病毒的全基因组测序。

乳头瘤病毒（PVs）是一类非常大的病毒，可引起人类和各种动物的皮肤和粘膜感染。在ro和马鹿中，大多数PV属于Deltapapillomavirus病毒属，并引起通常被称为纤维乳头瘤的肿瘤改变。尽管欧洲和其他地区的鱼籽和马鹿分布广泛，但有关这些物种中PV的广泛分布和PV基因组遗传变异的科学文献数据却很少。这项研究描述了鱼卵和马鹿中的皮肤纤维乳头瘤病病例，其临床表现是PVs感染的典型表现。在所有情况下，使用PCR确认PV DNA的存在，然后对部分L1进行Sanger测序基因。使用下一代测序技术在所有研究的样品中确定了完整的PV基因组，揭示了CcaPV1型感染ro和CePV1v型变异感染马鹿。将此处报道的完整CcaPV1型和CePV1v型变异基因组序列与GenBank中已有的完整基因组序列进行比较后，发现它们在时间和空间上具有很好的遗传稳定性。