LncRNAs are of functional long non-coding RNAs, which have been shown to be involved in critical pathways in cancer development. LncRNA-HOTAIR gene overexpression has been reported in several cancers. The aim of this study was to evaluate the associations between two variants of lncRNA-HOTAIR (rs1899663 G>T and rs4759314 A>G) gene polymorphisms and the risk of ovarian cancer (OC) susceptibility. We performed a case and control analysis on two hundred individuals consisting of 100 cases with OC and 100 women cancer-free in East Azerbaijan of Iranian population. To evaluate the association between two SNPs of lncRNA-HOTAIR with the risk of OC susceptibility used the polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) method. We revealed that two SNPs in the lncRNA-HOTAIR gene were significantly associated with the risk of OC. The dominant model of rs4759314 in lncRNA-HOTAIR (AA vs. GA/GG) showed a significantly increased risk with an OR of 10.036 (CI 2.253–44.712, P = 0.000); the recessive model of rs1899663 (TT vs. GT/GG) revealed a significantly increased risk with OR of 0.910 (CI 0.856–0.968; P = 0.002). In addition, our findings demonstrated that the 4759314G (OR 13.500; CI 3.146–57.940; P = 0.000) and 1899663T (OR 3.273; CI 1.433–7.475; P = 0.003) alleles are increased the risk of OC susceptibility. Our findings provide evidence that the specific genetic variants in lncRNA-HOTAIR gene may affect OC susceptibility in an Iranian population.

LncRNA具有功能性长非编码RNA，已被证明与癌症发展的关键途径有关。LncRNA-HOTAIR基因过表达在几种癌症中都有报道。这项研究的目的是评估lncRNA-HOTAIR（rs1899663 G> T和rs4759314 A> G）基因多态性的两个变异与卵巢癌（OC）易感性风险之间的关联。我们在伊朗人口的东阿塞拜疆对200例个体进行了病例和对照分析，其中包括100例OC病例和100例无癌女性。评估lncRNA-HOTAIR的两个SNP之间的关联具有OC易感性的风险使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法。我们发现，lncRNA-HOTAIR基因中的两个SNP与OC风险显着相关。lncRNA-HOTAIR中rs4759314的优势模型（AA vs. GA / GG）显示风险显着增加，OR为10.036（CI 2.253–44.712，P = 0.000）；rs1899663的隐性模型（TT与GT / GG）显示风险显着增加，OR为0.910（CI 0.856-0.968； P = 0.002）。此外，我们的发现表明，4759314G（OR 13.500; CI 3.146–57.940; P = 0.000）和1899663T（OR 3.273; CI 1.433–7.475; P = 0.003）等位基因增加了OC易感性的风险。我们的发现提供了证据，表明特定的遗传变异lncRNA-HOTAIR基因可能会影响伊朗人群的OC敏感性。