Brain-derived neurotrophic factor (BDNF) is known to control a wide variety of brain functions, ranging from memory formation to food intake. However, since the BDNF levels are extremely low in the nervous system, the dynamics in neurons from intracellular trafficking to secretion is absolutely complicated; the understanding is not fully promoted. We here review the findings of those critical mechanisms from intracellular trafficking to the secretion of BDNF. Furthermore, to solve this issue, technological advances for the detection, measurement, and imaging of this growth factor are essential. We believe that this review helps the study of these complex but critical mechanisms of BDNF.

中文翻译：

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脑源性神经营养因子之旅：从细胞内运输到分泌

众所周知，脑源性神经营养因子 (BDNF) 可以控制多种大脑功能，从记忆形成到食物摄入。然而，由于神经系统中 BDNF 的水平极低，神经元从细胞内运输到分泌的动力学绝对复杂；理解没有得到充分促进。我们在这里回顾了从细胞内运输到 BDNF 分泌的那些关键机制的发现。此外，为了解决这个问题，这种生长因子的检测、测量和成像技术进步是必不可少的。我们相信这篇综述有助于研究 BDNF 的这些复杂但关键的机制。