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Journey of brain-derived neurotrophic factor: from intracellular trafficking to secretion

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Abstract

Brain-derived neurotrophic factor (BDNF) is known to control a wide variety of brain functions, ranging from memory formation to food intake. However, since the BDNF levels are extremely low in the nervous system, the dynamics in neurons from intracellular trafficking to secretion is absolutely complicated; the understanding is not fully promoted. We here review the findings of those critical mechanisms from intracellular trafficking to the secretion of BDNF. Furthermore, to solve this issue, technological advances for the detection, measurement, and imaging of this growth factor are essential. We believe that this review helps the study of these complex but critical mechanisms of BDNF.

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Funding

This work was supported by the Japan Science and Technology Agency Core Research for Evolutional Science and Technology (CREST) (to M.K. and T.F.); AMED under Grant Number JP20lm0203012j0002 (to M.K.); a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan (17K07073) (to M.K.) and (17H03563) (to T.F.); and The NOVARTIS Foundation (Japan) for the Promotion of Science (T.F.).

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  1. Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorioka, Ikeda, Osaka, 563-8577, Japan

    Masami Kojima & Toshiyuki Mizui

  2. Core Research for Evolutional Science and Technology (CREST), Kawaguchi, 332-0012, Japan

    Masami Kojima, Toshiyuki Mizui & Teiichi Furuichi

  3. Graduate School of Frontier Bioscience, Osaka University, Suita, 565-0871, Japan

    Masami Kojima

  4. Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan

    Chiaki Ishii, Yoshitake Sano & Teiichi Furuichi

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  1. Masami Kojima
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Kojima, M., Ishii, C., Sano, Y. et al. Journey of brain-derived neurotrophic factor: from intracellular trafficking to secretion. Cell Tissue Res 382, 125–134 (2020). https://doi.org/10.1007/s00441-020-03274-x

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