Islet of Langerhans transplantation as a cell therapy for type 1 diabetes faces obstacles that have prevented full and lasting engraftment in the liver, the currently preferred implantation site in clinical practice. Yu and colleagues circumvent these issues and achieve stable diabetes reversal by transplanting islets encapsulated in a simple collagen-based matrix into the more accessible subcutaneous space.

中文翻译：

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我让你在我的皮肤下。

Langerhans岛胰岛移植作为1型糖尿病的细胞疗法面临着障碍，这些障碍阻止了肝脏在临床实践中目前首选的植入部位全面和持久地植入肝脏。Yu及其同事通过将封装在基于胶原蛋白的简单基质中的胰岛移植到更易接近的皮下空间中，从而规避了这些问题并实现了稳定的糖尿病逆转。