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ISLET TRANSPLANTATION

I’ve got you under my skin

Nature Metabolism volume 2, pages 993–994 (2020)Cite this article

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Islet of Langerhans transplantation as a cell therapy for type 1 diabetes faces obstacles that have prevented full and lasting engraftment in the liver, the currently preferred implantation site in clinical practice. Yu and colleagues circumvent these issues and achieve stable diabetes reversal by transplanting islets encapsulated in a simple collagen-based matrix into the more accessible subcutaneous space.

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Fig. 1: Transplantation of islets of Langerhans in the subcutaneous site: how it works and how it can develop.

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Acknowledgements

This work is supported by grants from the Swiss National Science Foundation (grant 310030_173138), the European Foundation for the Study of Diabetes (EFSD), the European Commission (Horizon 2020 Framework Program; VANGUARD grant 874700), the Juvenile Diabetes Research Foundation (JDRF; grant 3-SRA-2020-926-S-B) and the Shota Rustaveli National Science Foundation (grant FR-19-19760).

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Authors and Affiliations

  1. Cell Isolation and Transplantation Center, Department of Surgery, University of Geneva School of Medicine, Geneva, Switzerland

    Thierry Berney & Ekaterine Berishvili

  2. Division of Transplantation, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland

    Thierry Berney

  3. Faculty Diabetes Center, University of Geneva School of Medicine, Geneva, Switzerland

    Thierry Berney & Ekaterine Berishvili

  4. Institute of Medical and Public Health Research, Ilia State University, Tbilisi, Georgia

    Ekaterine Berishvili

Authors
  1. Thierry Berney
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  2. Ekaterine Berishvili
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Both authors contributed equally to the writing of the manuscript.

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Correspondence to Thierry Berney.

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The authors declare no competing interests.

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Berney, T., Berishvili, E. I’ve got you under my skin. Nat Metab 2, 993–994 (2020). https://doi.org/10.1038/s42255-020-0268-8

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