Abstract

One of the complications of type 2 diabetes mellitus in men is steroidogenic and spermatogenic dysfunctions. There is evidence of a restoring effect of the antidiabetic drug metformin on them. We studied the effect of MF therapy (4 weeks, 200 mg/kg/day) on the hormonal parameters of the gonad axis and on the morphological characteristics of epididymal spermatozoa in male rats with a severe form of T2DM caused by a high-fat diet and a low-dose streptozotocin. It has been shown that MF therapy, along with the restoration of the metabolic parameters, normalizes the plasma levels of testosterone and leptin and the content of testosterone, its precursors, leptin and its receptors in the testes, and also increases sperm motility, which is reduced in T2DM. This is the result of both the systemic action of MF and its direct effect on testicular cells.

中文翻译：

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二甲双胍治疗条件下雄性2型糖尿病大鼠睾丸类固醇生成和精子生成正常化。

摘要

男性2型糖尿病的并发症之一是类固醇生成和生精功能障碍。有证据表明抗糖尿病药物二甲双胍对它们具有恢复作用。我们研究了MF治疗（4周，200 mg / kg /天）对雄性大鼠高脂饮食引起的重型T2DM的性腺轴激素参数和附睾精子形态特征的影响和低剂量的链脲佐菌素。已经证明，MF疗法以及代谢参数的恢复使睾丸激素和瘦素的血浆水平以及睾丸中睾丸激素，其前体，瘦素及其受体的含量正常化，并且还增加了精子运动，这是减少了T2DM。这是MF的全身作用及其对睾丸细胞直接作用的结果。