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Normalization of Testicular Steroidogenesis and Spermatogenesis in Male Rats with Type 2 Diabetes Mellitus under the Conditions of Metformin Therapy

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Abstract

One of the complications of type 2 diabetes mellitus in men is steroidogenic and spermatogenic dysfunctions. There is evidence of a restoring effect of the antidiabetic drug metformin on them. We studied the effect of MF therapy (4 weeks, 200 mg/kg/day) on the hormonal parameters of the gonad axis and on the morphological characteristics of epididymal spermatozoa in male rats with a severe form of T2DM caused by a high-fat diet and a low-dose streptozotocin. It has been shown that MF therapy, along with the restoration of the metabolic parameters, normalizes the plasma levels of testosterone and leptin and the content of testosterone, its precursors, leptin and its receptors in the testes, and also increases sperm motility, which is reduced in T2DM. This is the result of both the systemic action of MF and its direct effect on testicular cells.

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Funding

This work was supported by the Russian Foundation for Basic Research and DNT (no. 18-515-45004 IND-a) and the state assignment AAAA-A18-118012290427-7. For the ELISA experiments, the equipment of the Center for Collective Use of the IEPB RAS was used.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry of Russian Academy of Sciences, 194223, St. Petersburg, Russia

    K. V. Derkach, A. A. Bakhtyukov, L. V. Bayunova, I. I. Zorina & A. O. Shpakov

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  1. K. V. Derkach
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  2. A. A. Bakhtyukov
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  3. L. V. Bayunova
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  4. I. I. Zorina
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  5. A. O. Shpakov
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Corresponding author

Correspondence to A. O. Shpakov.

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STATEMENT ON THE WELFARE OF ANIMALS

All procedures for the care and use of animals were performed in an accordance with the requirements of the Ethics Committee of the IEFB RAS (Protocol no. 2/3-2019, March 29, 2019), the European Communities Council Directive 1986 (86/609/EEC) and the “Guide for the Care and Use of Laboratory Animals”.

CONFLICT OF INTEREST

Authors report no conflicts of interest.

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Derkach, K.V., Bakhtyukov, A.A., Bayunova, L.V. et al. Normalization of Testicular Steroidogenesis and Spermatogenesis in Male Rats with Type 2 Diabetes Mellitus under the Conditions of Metformin Therapy. Dokl Biol Sci 493, 110–113 (2020). https://doi.org/10.1134/S0012496620040031

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  • DOI: https://doi.org/10.1134/S0012496620040031

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