Functionalized implants demonstrate an upgraded approach in orthopedic implants, aiming to achieve long term success through improved bio integration. Bioceramic coatings with multifunctionality have arisen as an effective substitute for conventional coatings, owing to their combination of various properties that are essential for bio-implants, such as osteointegration and antibacterial character. In the present study, thin hopeite coatings were produced by Pulsed laser deposition (PLD) and radio frequency magnetron sputtering (RFMS) on Ti64 substrates. The obtained hopeite coatings were annealed at 500 °C in ambient air and studied in terms of surface morphology, phase composition, surface roughness, adhesion strength, antibacterial efficacy, apatite forming ability, and surface wettability by scanning electron microscope (SEM), X-ray diffraction (XRD), atomic force microscope (AFM), tensometer, fluorescence-activated cell sorting (FACS), simulated body fluid (SBF) immersion test and contact angle goniometer, respectively. Furthermore, based on promising results obtained in the present work it can be summarized that the new generation multifunctional hopeite coating synthesized by two alternative new process routes of PLD and RFMS on Ti64 substrates, provides effective alternatives to conventional coatings, largely attributed to strong osteointegration and antibacterial character of deposited hopeite coating ensuring the overall stability of metallic orthopedic implants.

功能化植入物展示了骨科植入物的升级方法，旨在通过改善生物整合来取得长期成功。具有多功能性的生物陶瓷涂层已经成为传统涂层的有效替代品，这是由于它们结合了生物植入物必不可少的各种特性，例如骨整合和抗菌特性。在本研究中，通过在Ti64基板上通过脉冲激光沉积（PLD）和射频磁控溅射（RFMS）制备了薄的希望石涂层。将获得的萤石涂层在环境空气中于500°C退火，并通过扫描电子显微镜（SEM）研究表面形态，相组成，表面粗糙度，粘附强度，抗菌功效，磷灰石形成能力和表面润湿性，X射线衍射（XRD），原子力显微镜（AFM），张力计，荧光激活细胞分选（FACS），模拟体液（SBF）浸没测试和接触角测角仪。此外，根据本工作获得的令人鼓舞的结果，可以总结出，通过在Ti64基底上通过PLD和RFMS的两种替代新工艺路线合成的新一代多功能希望石涂层，可提供常规涂层的有效替代方案，这在很大程度上归因于强大的骨整合性和沉积的希望石涂层的抗菌特性可确保金属骨科植入物的整体稳定性。