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Multifunctional hopeite nanocoating on Ti64 substrates by pulsed laser deposition and radio frequency magnetron sputtering for orthopedic implant applications: A comparative study

利用脉冲激光沉积和射频磁控溅射在Ti64 基底上 制备多功能磷锌矿纳米涂层于骨科植入物的比较研究

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Abstract

Functionalized implants demonstrate an upgraded approach in orthopedic implants, aiming to achieve long term success through improved bio integration. Bioceramic coatings with multifunctionality have arisen as an effective substitute for conventional coatings, owing to their combination of various properties that are essential for bio-implants, such as osteointegration and antibacterial character. In the present study, thin hopeite coatings were produced by Pulsed laser deposition (PLD) and radio frequency magnetron sputtering (RFMS) on Ti64 substrates. The obtained hopeite coatings were annealed at 500 °C in ambient air and studied in terms of surface morphology, phase composition, surface roughness, adhesion strength, antibacterial efficacy, apatite forming ability, and surface wettability by scanning electron microscope (SEM), X-ray diffraction (XRD), atomic force microscope (AFM), tensometer, fluorescence-activated cell sorting (FACS), simulated body fluid (SBF) immersion test and contact angle goniometer, respectively. Furthermore, based on promising results obtained in the present work it can be summarized that the new generation multifunctional hopeite coating synthesized by two alternative new process routes of PLD and RFMS on Ti64 substrates, provides effective alternatives to conventional coatings, largely attributed to strong osteointegration and antibacterial character of deposited hopeite coating ensuring the overall stability of metallic orthopedic implants.

摘要

功能化种植体展示了骨科种植体的升级方法,旨在通过改进生物整合实现长期成功。多功能的 生物陶瓷涂层由于其结合了生物植入物所必需的各种性能,如骨整合和抗菌特性,已成为传统涂层的 有效替代品。本文利用脉冲激光沉积(PLD)和射频磁控溅射(RFMS)在Ti64 基底上制备了薄磷锌矿涂 层。使磷锌矿涂层在500 °C 的真空中退火,并分别通过扫描电子显微镜(SEM)、X 射线衍射(XRD)、 原子力显微镜(AFM)、张力计、荧光激活细胞排序(流式细胞仪)、模拟体液(SBF)浸泡试验和接触角 测角仪研究表面形态、相组成、表面粗糙度、粘附强度、抗菌功效、磷灰石形成能力和表面润湿性能。 结果表明,在Ti64 基底上由PLD 和RFMS 两种新工艺路线合成的新一代多功能磷锌矿涂层是传统涂 层的有效替代品。所沉积的磷锌矿涂层具有较强的骨整合能力和抗菌特性,保证了金属骨科种植体的 整体稳定性。

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Acknowledgements

We express our sincere thanks to MNNIT Allahabad, IIT Kanpur, RRCAT Indore, MHRD GOI and UOJ South Africa for their valuable support during the entire duration of the study.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Motilal Nehru National Institute of Technology, Allahabad, 211004, India

    Ashish Das & Mukul Shukla

  2. Department of Production and Industrial Engineering, National Institute of Technology, Jamshedpur, 831014, India

    Ashish Das

  3. School of Mechanical and Aerospace Engineering, Queen’s University, Belfast, BT7 1NN, UK

    Mukul Shukla

  4. Department of Mechanical Engineering Technology, University of Johannesburg, Johannesburg, PO Box 524, South Africa

    Mukul Shukla

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  1. Ashish Das
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Das, A., Shukla, M. Multifunctional hopeite nanocoating on Ti64 substrates by pulsed laser deposition and radio frequency magnetron sputtering for orthopedic implant applications: A comparative study. J. Cent. South Univ. 27, 2198–2209 (2020). https://doi.org/10.1007/s11771-020-4441-8

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