Abstract

Necessary precursors for obtaining tritium-labeled Z-Gly-Pro-DOPA, Z-Gly-Pro-SRT, Z-Gly-Pro-Dox, OL-Gly-Pro-DOPA,Ol-Gly-Pro-Srt were synthesized for the first time (Gly stands for glycine; Pro, proline; Ol, Oleic acid, DOPA, dopamine; Dox, Doxorubicin; Srt, Serotonin; and Z, benzyloxycarbonyl protection). The tritium-labeled proline and glycine were used to synthesize peptide derivatives of DOPA, Dox, and Srt with different tritium distributions.

中文翻译：

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Hydro标记的多巴胺，5-羟色胺和阿霉素衍生物含有在氢化条件下不稳定的片段

摘要

合成了获得tri标记的Z-Gly-Pro-DOPA，Z-Gly-Pro-SRT，Z-Gly-Pro-Dox，OL-Gly-Pro-DOPA，Ol-Gly-Pro-Srt所需的前体。第一次（Gly代表甘氨酸； Pro代表脯氨酸； Ol代表油酸； DOPA代表多巴胺； Dox代表阿霉素； Srt代表5-羟色胺； Z代表苄氧羰基保护）。tri标记的脯氨酸和甘氨酸用于合成DO分布不同的DOPA，Dox和Srt肽衍生物。