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Tritium-Labeled Dopamine, Serotonin, and Doxorubicine Derivatives Containing Fragments Unstable under Hydrogenation Conditions

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Radiochemistry Aims and scope

Abstract

Necessary precursors for obtaining tritium-labeled Z-Gly-Pro-DOPA, Z-Gly-Pro-SRT, Z-Gly-Pro-Dox, OL-Gly-Pro-DOPA,Ol-Gly-Pro-Srt were synthesized for the first time (Gly stands for glycine; Pro, proline; Ol, Oleic acid, DOPA, dopamine; Dox, Doxorubicin; Srt, Serotonin; and Z, benzyloxycarbonyl protection). The tritium-labeled proline and glycine were used to synthesize peptide derivatives of DOPA, Dox, and Srt with different tritium distributions.

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Funding

The study was carried out with partial support of the Basic Research Programs of the Presidium of the Russian Academy of Sciences “Innovative developments in biomedicine” and “Postgenome technologies and promising solutions in biomedicine.”

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Authors and Affiliations

  1. Institute of Molecular Genetics, Russian Academy of Sciences, 123182, Moscow, Russia

    V. P. Shevchenko, L. A. Andreeva, K. V. Shevchenko, I. Yu. Nagaev & N. F. Myasoedov

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  1. V. P. Shevchenko
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  2. L. A. Andreeva
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  3. K. V. Shevchenko
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  4. I. Yu. Nagaev
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  5. N. F. Myasoedov
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Correspondence to V. P. Shevchenko.

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Shevchenko, V.P., Andreeva, L.A., Shevchenko, K.V. et al. Tritium-Labeled Dopamine, Serotonin, and Doxorubicine Derivatives Containing Fragments Unstable under Hydrogenation Conditions. Radiochemistry 62, 539–542 (2020). https://doi.org/10.1134/S1066362220040116

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  • DOI: https://doi.org/10.1134/S1066362220040116

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