Schizophrenia (SCZ) is a destructive neuropsychiatric illness affecting millions of people worldwide. The correlation between RELN gene polymorphisms and SCZ was investigated by previous researches, though the results remained conflicting. Based on the available studies, we conducted this meta-analysis to provide a more comprehensive outcome on whether the RELN gene polymorphisms (rs7341475 and rs262355) are associated with SCZ. A total of 15 studies with 25,403 subjects (9047 cases and 16,356 controls) retrieved from PubMed, ScienceDirect, EMBASE, Wiley, BMC, Cochrane, Springer, MDPI, SAGE, and Google Scholar up to June 2020 were included. Meta-analysis was performed using Review Manager 5.3. The heterogeneity was checked using I² statistics and Q-test, whereas publication bias was also measured. The rs7341475 polymorphism showed a significantly lower risk for SCZ for the allele (A vs. G: OR = 0.93, 95%CI = 0.87–0.99), codominant 1 (AG vs. GG: OR = 0.92, 95%CI = 0.85–0.99), dominant model (AA+AG vs. GG: OR = 0.92, 95%CI = 0.86–0.98), and over dominant model (AG vs. AA+GG: OR = 0.92, 95%Cl = 0.86–0.99). The allele, codominant model 1, and dominant models remained statistically significant after the correction of the Bonferroni (p < 0.025). Subgroup analysis confirmed the association of allele and dominant models in the Caucasian after Bonferroni correction. For rs262355 polymorphism, a significantly increased risk of SCZ was found only in Caucasians for codominant 2, dominant, and allele models, but significance exists only for the allele model after Bonferroni correction. Publication bias was found in the case of codominant 2 and recessive models for rs7341475 in the overall population, but this publication was not found after performing the Bonferroni correction or after performing the subgroup analysis. No such publication was found for rs262355. The results suggest that RELN rs7341475 is associated with a lower risk of SCZ in the overall population and Caucasian population, but rs262355 is associated with an increased risk of SCZ only in the Caucasian population.

精神分裂症 (SCZ) 是一种破坏性的神经精神疾病，影响着全世界数百万人。先前的研究已经研究了 RELN 基因多态性与 SCZ 之间的相关性，但结果仍然相互矛盾。基于现有的研究，我们进行了这项荟萃分析，以提供关于 RELN 基因多态性（rs7341475 和 rs262355）是否与 SCZ 相关的更全面的结果。截至 2020 年 6 月，从 PubMed、ScienceDirect、EMBASE、Wiley、BMC、Cochrane、Springer、MDPI、SAGE 和 Google Scholar 中检索到的 15 项研究共 25,403 名受试者（9047 例病例和 16,356 名对照者）被纳入。使用 Review Manager 5.3 进行 Meta 分析。使用I ²统计量和Q检验异质性-test，同时也测量了发表偏倚。rs7341475 多态性显示等位基因（A 对 G：OR = 0.93，95%CI = 0.87-0.99）、共显性 1（AG 对 GG：OR = 0.92，95%CI = 0.85-）的 SCZ 风险显着降低0.99)、显性模型（AA+AG vs. GG：OR = 0.92、95%CI = 0.86–0.98）和过度显性模型（AG vs. AA+GG：OR = 0.92、95%Cl = 0.86–0.99） . 等位基因、共显性模型 1 和显性模型在经 Bonferroni ( p < 0.025)。亚组分析证实了 Bonferroni 校正后白种人中等位基因和显性模型的关联。对于 rs262355 多态性，仅在白种人的共显性 2、显性和等位基因模型中发现 SCZ 风险显着增加，但仅在 Bonferroni 校正后的等位基因模型中才具有显着性。在总体人群中 rs7341475 的共显性 2 和隐性模型的情况下发现了发表偏倚，但在执行 Bonferroni 校正或执行亚组分析后未发现该出版物。未找到 rs262355 的此类出版物。结果表明，RELN rs7341475 与总体人群和高加索人群中较低的 SCZ 风险相关，但 rs262355 仅与高加索人群中 SCZ 的风险增加相关。