Objectives

The current study is to estimate the bisoprolol (BOP) oral treatment of rats against the myocardial infarction (MI) administrated by using isoproterenol (ISO).

Methods

Treatment of rats are MI administration by subcutaneous for two successive days of ISO (85 mg/kg). The tissue of heart is removed without delay, it is washed used isotonic chilled saline in this study. Plasma is separated from the collected rat blood and further analysis of biochemical parameters were carried out.

Results

Group of ISO-treated rats have increased levels of glucose in blood, also observed the activity of lipids in plasma along fibres of muscle with hyalinization, compared to BOP treated rats, and ISO + BOP treated rats. The parameter values of BOP administered rat were close to control rats. Reports clearly state that ISO + BOP treated rat tissue of heart damage is reduced when compared to ISO treated rats.

Conclusions

Rats were treated with ISO + BOP to defend against hyperlipidaemia and tissue of cardiac damage and followed by MI. Hence, to investigate the biochemical and biophysical BOP mechanism against MI risk in rats.

中文翻译：

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比索洛尔口服治疗心力衰竭大鼠：钙调蛋白的参与。

目标

当前的研究是评估比索洛尔（BOP）对大鼠的异丙酚（ISO）所致心肌梗塞（MI）的口服治疗。

方法

大鼠的治疗是通过连续两天的ISO（85 mg / kg）皮下进行MI给药。在本研究中，将心脏组织立即取出，用等渗的冷盐水冲洗。从收集的大鼠血液中分离血浆，并进行生化参数的进一步分析。

结果

与BOP处理的大鼠和ISO + BOP处理的大鼠相比，经ISO处理的大鼠组的血液中葡萄糖水平升高，还观察到了透明质酸沿肌肉纤维的血浆脂质活性。BOP给药大鼠的参数值接近于对照大鼠。报道清楚地表明，与ISO处理的大鼠相比，ISO + BOP处理的大鼠心脏损伤组织减少了。

结论

用ISO + BOP处理大鼠以防御高脂血症和心脏损害组织，然后进行MI。因此，研究大鼠抗MI风险的生化和生物物理BOP机制。