Original article
Bisoprolol oral treatment of heart failure rats: Involvement of calmodulin

https://doi.org/10.1016/j.jksus.2020.08.017Get rights and content
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Abstract

Objectives

The current study is to estimate the bisoprolol (BOP) oral treatment of rats against the myocardial infarction (MI) administrated by using isoproterenol (ISO).

Methods

Treatment of rats are MI administration by subcutaneous for two successive days of ISO (85 mg/kg). The tissue of heart is removed without delay, it is washed used isotonic chilled saline in this study. Plasma is separated from the collected rat blood and further analysis of biochemical parameters were carried out.

Results

Group of ISO-treated rats have increased levels of glucose in blood, also observed the activity of lipids in plasma along fibres of muscle with hyalinization, compared to BOP treated rats, and ISO + BOP treated rats. The parameter values of BOP administered rat were close to control rats. Reports clearly state that ISO + BOP treated rat tissue of heart damage is reduced when compared to ISO treated rats.

Conclusions

Rats were treated with ISO + BOP to defend against hyperlipidaemia and tissue of cardiac damage and followed by MI. Hence, to investigate the biochemical and biophysical BOP mechanism against MI risk in rats.

Abbreviations

BOP
bisoprolol
MI
myocardial infarction
ISO
isoproterenol
LDL-C
cholesterol with lesser density
HDL-C
high density of lipoprotein cholesterol
CVD
cardiovascular diseases
LV
left ventricular
COPD
chronic obstructive pulmonary disease
CaM
calmodulin
NCLAS
national centre for laboratory animal sciences
AC
air condition
TG
triglycerides
CK
creatinine kinase
LDH
lactate dehydrogease
AST
aspartate transaminase
ALT
alanine transaminase
NAD
nicotinamide adenine dinucleotide
DNPH
2,4-dinitrophenylhydrazine
CaCaM
canonical Ca2+ loaded CaM

Keywords

Bisoprolol
Heart failure
ISO
Glucose
Lipids

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Peer review under responsibility of King Saud University.