Ruthenium(II)-catalyzed acyloxylation of the ortho-C–H bond in 2-aroyl-imidazoles with carboxylic acids,Organic Chemistry Frontiers

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Ruthenium(II)-catalyzed acyloxylation of the ortho-C–H bond in 2-aroyl-imidazoles with carboxylic acids
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-08-31 , DOI: 10.1039/d0qo00920b
Chen-an Wang _{1,

2,

3,

4,

5} , Naoto Chatani _{1,

2,

3,

4,

5}

Affiliation

The reaction of 2-aroyl-imidazoles with carboxylic acids using [RuCl₂(p-cymene)]₂ as the catalyst and Ag₂CO₃ as the oxidant results in ortho-C–H acyloxylation to afford acyloxylation products, in which the imidazole group functions as a directing group. A wide range of functional groups are tolerated in the reaction. The directing group can be easily converted to the corresponding esters under mild conditions.

中文翻译：

钌（II）催化2-芳酰基咪唑中邻位C–H键与羧酸的酰氧基化

以[RuCl ₂（p- Cymene）] ₂为催化剂，Ag ₂ CO ₃为氧化剂，使2-芳酰基-咪唑与羧酸反应，导致邻-C-H酰氧基化，得到酰氧基化产物，其中咪唑组充当指挥组。反应中可以容忍多种官能团。在温和条件下，该导向基团可以容易地转化成相应的酯。

更新日期：2020-09-30

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