Issue 19, 2020
From the journal:

Organic Chemistry Frontiers

Ruthenium(ii)-catalyzed acyloxylation of the ortho-C–H bond in 2-aroyl-imidazoles with carboxylic acids†‡

Chen-an Wanga  and  Naoto Chatani ORCID logo *a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan
E-mail: chatani@chem.eng.osaka-u.ac.jp

Abstract

The reaction of 2-aroyl-imidazoles with carboxylic acids using [RuCl2(p-cymene)]2 as the catalyst and Ag2CO3 as the oxidant results in ortho-C–H acyloxylation to afford acyloxylation products, in which the imidazole group functions as a directing group. A wide range of functional groups are tolerated in the reaction. The directing group can be easily converted to the corresponding esters under mild conditions.

Graphical abstract: Ruthenium(ii)-catalyzed acyloxylation of the ortho-C–H bond in 2-aroyl-imidazoles with carboxylic acids

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Article information

DOI
https://doi.org/10.1039/D0QO00920B
Article type
Research Article
Submitted
31 Jul 2020
Accepted
31 Aug 2020
First published
31 Aug 2020

Org. Chem. Front., 2020,7, 2955-2959

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Ruthenium(II)-catalyzed acyloxylation of the ortho-C–H bond in 2-aroyl-imidazoles with carboxylic acids

C. Wang and N. Chatani, Org. Chem. Front., 2020, 7, 2955 DOI: 10.1039/D0QO00920B

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